The efficiencies of treating high-concentration soybean processing wastewater (30~160L/d) by a side-stream anaerobic membrane bioreactor (AnMBR) were studied for over 240 days. AnMBR was comprised of a expanded granular sludge bed reactor and a side-stream hyperfiltration membrane module.The effects of hydraulic retention time (HRT) on the system performance and efficiencies of different cleaning methods on the membrane fouling were explored. The optimal HRT was found to be about 18 h at 10 g COD/L feeding (OLR was about 13.6 kg COD /(m3•d)). During stable operational periods, approximate 70% methane was found in the biogas with an overall gas yield of 0.10~0.25 L/g COD. The operating conditions of membrane module with 0.1MPa operating pressure and the cleaning efficiencies of membrane fouling were studied. However, for different membrane cleaning methods, the study showed it could acquire approximate 90 percents flux recovery at the best condition.