Membrane Science and Technology

Position：Home >> Abstract

Synthesis and biocompatibility of phosphorylcholine polymer membranes

Authors： LI Lin, XIN Zhong*, WANG Junhua

Units： State Key Laboratory of Chemical Engineering, School of chemical engineering, East China University of Science and Technology, Shanghai 200237, China

KeyWords： phosphorylcholine; platelet adhesion; equilibrium water content; biocompatibility

ClassificationCode：TQ316.6

year,volume(issue):pagination： 2012, 32(1):40-45

Abstract：

2-methacryloyloxyethyl phosphorylcholine (MPC) was copolymerized with butyl methacrylate (BMA) and 2-ethylhexyl methacrylate (EHMA), respectively, using 2, 2’-azodiisobutyronitrile (AIBN) as the initiator, in order to research the biocompatibility of the phosphorylcholine polymers. The chemical structures of the polymers were characterized by the IR, 1H-NMR and elemental analyses. The solubility of the polymers in different solvents was also investigated, which provided the evidence for the purification of these polymers. Polymer membranes were prepared by solvent evaporation method. The platelet rich plasma (PRP) contact studies showed that the adhesion of platelets on the surfaces of MPC polymer membranes was reduced compared to the polymers without MPC unit, which showed good blood compatibility. The equilibrium water content (EWC) of the MPC polymer membranes increased with increases in the MPC mole fraction, and this value for PMB20 polymer membrane (MPC mole fraction: 18%) reached 47%. The high water content of phosphorylcholine polymers is one of the reasons for the good biocompatibility of the membranes.

Funds：

国家自然科学基金项目（21006025）

AuthorIntro：

李琳（1983-），女，内蒙古人，博士生，从事具有生物相容性薄膜的制备研究。*通讯联系人， E-mail: xzh@ecust.edu.cn

Reference：

[1] Costerton J W, Lewandowski Z. Microbial biofilms [J]. Annual Review of Microbiology, 1995, 49(1): 711-747.
[2] Herrwerth S, Eck W, Reinhardt S, et al. Factors that determine the protein resistance of oligoether self-assembled monolayers − internal hydrophilicity, terminal hydrophilicity, and lateral packing density [J]. Journal of the American Chemical Society, 2003, 125(31): 9359-9366.
[3] Ishihara K, Ueda T, Nakabayashi N. Preparation of phospholipid polymers and their properties as polymer hydrogel membranes [J]. Polymer Journal, 1990, 22(5): 355-360.
[4] Kobayashi K. Segmented polyurethane modified by photopolymerization and cross-linking with 2-methacryloyloxyethyl phosphorylcholine polymer for blood-contacting surfaces of ventricular assist devices [J]. Journal of Artificial Organs, 2005, 8(4): 237-244.
[5] Ye S H, Watanabe J, Iwasaki Y, et al. Novel cellulose acetate membrane blended with phospholipid polymer for hemocompatible filtration system [J]. Journal of Membrane Science, 2002, 210(2): 411-421.
[6] Konno T, Kurita K, Iwasaki Y, et al. Preparation of nanoparticles composed with bioinspired 2-methacryloyloxyethyl phosphorylcholine polymer [J]. Biomaterials, 2001, 22(13): 1883-1889.
[7] Fudan University. Electrochemical luminescence composite material with anti-biofouling properties [P]. US, Application Publication, US2006029979 (A1). 2006.02.09.
[8] L'OREAL. Copolymers of polyolefine/phosphorylcholine in cosmetic compositions [P]. EU, Application Publication, WO2006106487 (A1). 2006.10.12.
[9] 王丽红,陈欢林.改善生物医用高分子膜表面血液相容性的PC技术[J].膜科学与技术,2006,26(3):90-94.
[10] 王俊华, 辛忠,李琳.MPC/MMA共聚物的合成及血液相容性[J].华东理工大学学报（自然科学版）,2010,36(4):506-511.
[11] Nakaya T, Li Yujun T. Recent progress of phospholipid polymers. [J]. Designed Monomers & Polymers, 2003, 6(4): 309-351.
[12] 蔡立彬.有机硅改性水凝胶角膜接触镜材料的研究[D]:[博士学位论文].西安:西北工业大学,2006：35.
[13] 张晓冬, 倪忠斌,李英，等.MMA/MPC共聚物膜的制备及其抗凝血性能研究[J].化学学报,2007,65(22):2623-2628.
[14] 吴雪.磷酰胆碱衍生物的制备及其亲水性能的初步研究[D]:[硕士学位论文].上海:华东理工大学,2008：15-28.
[15] 谭鸿.新型生物医用聚氨酯的合成、结构与性能研究[D]:[博士学位论文].成都:四川大学,2004：156.
[16] Long S F, Clarke S, Davies M C, et al. Controlled biological response on blends of a phosphorylcholine-based copolymer with poly(butyl methacrylate) [J]. Biomaterials, 2003, 25(21): 5125-5135.
[17] Ruiz L, Hilborn J G, LIonard D, et al. Synthesis, structure and surface dynamics of phosphorylcholine functional biomimicking polymers [J]. Biomaterials, 1998, 19(11): 987-998.
[18] Inoue Y, Watanabe J, Ishihara K. Dynamic motion of phosphorylcholine groups at the surface of poly(2-methacryloyloxyethyl phosphorylcholine–random–2,2,2-trifluoroethyl methacrylate) [J]. Journal of Colloid and Interface Science, 2004, 31(12): 3274-3280.
[19] Wang T, Wang Y, Su Y, et al. Improved protein-adsorption-resistant property of pes/spc blend membrane by adjustment of coagulation bath composition [J]. Colloids and Surfaces B, 2005, 351(1): 141-148.
[20] Zhu A, Wang S, Yuan Y, et al. Cell adhesion behavior of chitosan surface modified by bonding 2-methacryloyloxyethyl phosphorylcholine. [J]. Journal of Biomaterials Science-Polymer Edition, 2002, 13(5): 501-510.

Service：

【Download】【Collect】

《膜科学与技术》编辑部 Address: Bluestar building, 19 east beisanhuan road, chaoyang district, Beijing; 100029 Postal code; Telephone：010-80492417/010-80485372; Fax：010-80485372 ; Email：mkxyjs@163.com