Endocrine disruption compounds bisphenol A solution was retained by the plasma modified polysulfone nanofiltration hollow fiber membrane. The rejection tests were at different factors including solution concentration, operating pressure，ionic strength and pH value. The retention rate and flux of bisphenol A solution retained by polysulphone nanofiltration hollow fiber membrane was observed after a long time. The mechanism of retention was analyzed and the retention rate and flux change rules made by changing different factors were concluded. The change of feed solution in different factors was investigated. The result showed that there was a very strong adsorption force between polysulfone nanofiltration hollow fiber membrane and bisphenol A. The adsorption was the main mechanism in the process for removing bisphenol A. And the rate of removal could reach more than 90% when it was in high concentration, pH=6, low ionic strength and the operating pressure was 0.2MP. The adsorption played a leading role in the process when it was close to neutral. Electrostatic repulsion existed in higher pH value. The influence of ionic strength on the adsorption was little.