Membrane Science and Technology

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Preparation and Characterization of Poly (L-lactic acid) (PLLA) Microporous Membrane for Dialysis

Authors： Ai-Lin Gao1,2，Fu Liu*1，Lin-Xin Xue*1

Units： 1、Ningbo Institute of Material Technology & Engineering, Chinese Academy of Sciences, 519 Zhuangshi Road, Ningbo 315201, China; 2、Ningbo University, 818 Fenghua road, Ningbo 315211, China

KeyWords： PLLA membrane; immersion precipitation; bio-compatibility; dialysis membrane

ClassificationCode：TQ028.8

year,volume(issue):pagination： 2013, 33(4):28-34

Abstract：

Bio-based Poly (l-lactic acid) (PLLA) for dialysis was prepared via immersion precipitation method in this work. The influences of the solvent including N-methyl pyrrolidone (NMP), N, N-dimethyl acetamide (DMAc) and 1, 4 – dioxane on the micro-structures of PLLA membrane were investigated. The influences of the pore former including Polyethylene glycol (PEG6000) and polyvinyl Pyrrolidone (PVP) on membrane morphologies, pore size, pure water flux and contact angle were investigated. Furthermore, the influences of Polyethylene glycol with different molecular weight (e.g. PEG600, PEG6000and PEG10000) on membrane morphologies, pore size, pure water flux were also investigated. SEM pictures showed that both NMP and DMAc could produce finger-like pores for PLLA membrane, while 1, 4–dioxane could cause the formation of cellular pores. PVP-K30 can make a more porous surface than PEG6000. PEG with different molecular weight will affect both the pore size and the surface layer thickness of PLLA film. The retention of PLLA membrane to urea, lysozyme and BSA was studied to simulate the dialysis process. All results indicated that bio-based PLLA membrane is promising to be the next generation of dialysis membrane with good bio-compatibility.

Funds：

国家自然科学基金（51273211），国家高技术研究发展计划（863计划，2012AA03A605），浙江省公益性技术应用研究计划项目（2011C31002）。

AuthorIntro：

高爱林（1989-），女，山东郯城人，硕士生，从事膜材料制备及应用研究。通讯联系人*，Email: fu.liu@nimte.ac.cn, xuelx@nimte.ac.cn,

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