In this study, porous support layer was prepared by immerse precipitation phase inversion method with polyester (PET) (100 μm) non-woven fabric as reinforced material, polysulfone (PS) as solute, dimethylformamide (DMF) and dimethylacetamide (DMAC) as solvents, pure water as coagulation bath, and the obtained porous support membrane was used to prepared seawater desalination reverse osmosis desalination membrane through interfacial polymerization technique. The morphological structure , pure water flux, specific surface area, pore volume, average pore size of the support layer , the compaction resistance of seawater desalination reverse osmosis membrane and and salt rejection and water flux of seawater desalination reverse osmosis membrane before and after compaction were measured and characterized. Results showed that compaction resistance of the support layer which was prepared using DMF as solvent was good and could be used for the preparation of seawater desalination reverse osmosis membran