In present paper, ceramic membrane with pore size of 50 nm was adopted to resource utilization the desizing wastewater, of which PMMA is the basis content. A two-stage series operation mode was employed, and the process was operated with recirculation and then concentration. The pseudo-steady fluxes of membranes in the first module and second module were 423 L•m-2•h-1and 453 L•m-2•h-1, respectively. Concentration operation was conducted after recirculation and, the fluxes of the two membranes were 66 L•m-2•h-1and 54 L•m-2•h-1 when the concentration ratio was 22. The membranes performed COD retention of 87.5% and the turbidity of the permeated water was lower than 1 NTU. No rejection was detected for the components with low molecular weight such as NaOH. It was found that the main membrane fouling was caused by the cake formation of PMMA on membrane surface, and the permeability recovered to be higher than 95%. The water produced by these ceramic membranes was reused to the production process, and the industrial scale membrane system run stably, economically showing good performance.