采用三种不同装填分率的聚偏氟乙烯中空纤维微孔膜组件，分别对溶菌酶溶液膜结晶过程进行实验研究，考察了不同装填分率下结晶溶液及洗脱液流速对溶剂跨膜通量和溶菌酶晶体质量的影响。结果表明，由于膜组件中纤维分布不均，导致低装填分率(12.4%)下结晶溶液流速在合适范围内的升高并不能有效提高跨膜通量，而对高装填分率（24.7%）下溶剂跨膜通量的影响不大；不同装填分率下溶剂跨膜通量都随着洗脱液流速的升高而增大。在较低的装填分率下，控制合适的结晶溶液流速及洗脱液流速均可以结晶制得质量较好的晶体。

The PVDF hollow fiber microporous membrane modules with three packing densities were employed to study the influences of the flow velocities of crystallization solution and stripping agent on membrane crystallization of lysozyme. It was found that, due to the different fiber distribution of membranes modules, the increase of flow velocity of crystallization solution in the appropriate range can’t improve effectively the transmembrane flux at a lower packing density(12.4%), and moreover, it had little effect at a higher packing density(24.7%).Transmembrane flux increased as flow velocity of stripping agent increased at different packing density. For the module with lower packing density, high quality crystals have been prepared under the proper flow velocities of crystallization solution and stripping agent.

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