膜科学与技术

气体分离膜材料用于ECMO氧合器的性能研究

作者：桑晨宇1,2，盛鲁杰2*，张文博3，孙健2，陈增胜3，马红超1*，李晖2，任吉中2

单位： 1. 大连工业大学轻工与化学工程学院，大连 116034； 2. 中国科学院大连化学物理研究所，大连 116023；
3. 北京航空航天大学生物力学与机械生物学教育部重点实验室，工业和信息化部先进医疗器械创新与转化重点实验室，国家先进医疗器械产教融合医学创新平台（医学与工程交叉学科），生物与医学工程学院，北京 100191

关键词： ECMO；膜式氧合器；气体分离膜；氟橡胶膜；血液相容性

DOI号： 10.16159/j.cnki.issn1007-8924.2026.03.014

分类号： TQ028.8

出版年,卷(期):页码： 2026, 46(3):138-148

摘要：

体外膜肺氧合（ECMO）作为一种关键的生命支持技术，其膜式氧合器的性能极大依赖于氧合膜材料的综合特性。本研究系统评估了聚丙烯腈（PAN）、聚醚酰亚胺（PEI）、聚砜（PSU）、聚4-甲基-1-戊烯（PMP）及氟橡胶（T8）多种商业化气体分离膜材料在热稳定性、表面润湿性、机械强度、血液相容性和气体渗透性等方面的表现。结果表明，五种商业化膜材料血液相容性良好，但气体渗透性能差异较大。PAN、PEI、PSU较差的气体渗透性能决定了其不能直接作为非对称膜应用于ECMO氧合器，但可以作为复合膜的多孔支撑层材料提供一定的机械强度。相对于商业化PMP膜，T8膜表现出更优的综合性能：其O2和CO2渗透系数分别高达1 029和2 464 Barrer，且具备优异的疏水性和热稳定性。在此基础上，成功制备了T8/PAN平板复合膜，通过SEM、AFM、接触角表征和气体渗透性能测试等分析表明，该复合膜具有良好的表面形貌、优异的疏水性和高气体通量，O2和CO2渗透通量分别达到1 770和3 122 GPU。该研究表明，氟橡胶膜材料具有较大的应用潜力，可作为下一代ECMO膜式氧合器的理想候选材料。

Extracorporeal membrane oxygenation (ECMO), as a critical life support technology, its oxygenation performance relies heavily on the comprehensive properties of the membrane materials. Here, the performance (such as thermal stability, surface wettability, mechanical strength, blood compatibility and gas permeability) of various commercial gas separation membrane materials was evaluated, including polyacrylonitrile (PAN), polyetherimide (PEI), polysulfone (PSU), poly-4-methyl-1-pentene (PMP) and fluororubber (T8). Results indicated that all five commercial membrane materials exhibited good blood compatibility, but their gas permeability varied significantly. The poor gas permeability of PAN, PEI, and PSU membranes precluded their direct use as asymmetric membranes in ECMO oxygenators, but they could serve as suitable support layers in composite membranes to provide stable mechanical strength. T8 membrane demonstrated outstanding performance compared to commercial PMP membrane: O2 and CO2 permeability reached 1 029 and 2 464 Barrer, respectively, with excellent hydrophobicity, moisture resistance and thermal stability. And T8 was coated onto PAN support substrate to fabricate composite membranes. Characterization via SEM, AFM, contact angle measurements, and gas permeability tests revealed that favorable surface morphology, outstanding hydrophobicity, and high gas permeance for the T8/PAN composite membranes. Their O2 and CO2 permeance reached 1 770 and 3 122 GPU, respectively. This study demonstrated that fluororubber holds significant application potential as an ideal candidate for next-generation ECMO membrane oxygenators.

基金项目：

新材料重大专项项目（2024ZD0603400）

作者简介：

第一作者简介：桑晨宇（2001-），男，河南安阳人，硕士研究生，主要从事气体分离膜研究.*通讯作者，盛鲁杰，E-mail：shenglujie@dicp.ac.cn；马红超，E-mail：m-h-c@sohu.com

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